Catch My Disease serves as a standout track on the 2005 soundtrack for the romantic comedy Just Friends. The song features Samantha James, whose vocal performance captures the film's lighthearted yet emotional tone. As part of a compilation that includes contributions from acts like Fountains of Wayne and The Lemonheads, the recording reflects the mid-2000s pop-rock aesthetic prevalent in movie soundtracks of that era. The track complements the narrative of the film through its melodic structure and accessible production, fitting seamlessly alongside other selections designed to underscore the story's romantic developments. This recording remains a notable song in the soundtrack's catalogue, highlighting the collaborative effort to create a cohesive musical backdrop for the movie's release.