Released by TLC, "Depend On My Self" stands as a defining track from the group's early era, showcasing their signature blend of R&B and hip-hop influences. The song features the distinctive vocal delivery of Lisa "Left Eye" Lopes, who delivers a sharp, rhythmic verse that highlights her lyrical prowess and became a staple of her solo work. As a key component of the group's discography, the recording captures the confident, empowering tone characteristic of TLC's breakthrough period in the 1990s. It remains a significant song in their catalog, reflecting the group's ability to merge female empowerment with catchy, danceable rhythms that resonated with audiences worldwide.