Released on the 2011 album Barton Hollow, "Poison & Wine" stands as a defining track in the career of The Civil Wars. The duo, Jeanne and Joy, crafted this recording with a haunting blend of country and folk elements, utilizing their signature close-harmony vocals to create an intimate and melancholic atmosphere. The song explores themes of toxic relationships and the bittersweet nature of love, resonating deeply within the Americana genre. Its raw emotional delivery and intricate acoustic arrangements helped propel The Civil Wars to critical acclaim and mainstream recognition, cementing their status as pioneers of modern folk revival. The track remains a staple of their discography, celebrated for its lyrical depth and the couple's unique vocal chemistry.